By Simon J. Evans

As the Brain Fitness industry continues to gain momentum, and people explore all the incredible brain-training tools being developed, we hope that enthusiasts don’t take their eye off the importance of the physical health of the brain and all the systems it communicates with. The brain is unique in that it houses our cognitive and emotional capacities in the form of the mind.

It is a ‘cognitive’ organ that hungers for stimulation from new experiences and challenges. Many brain fitness programs strive to satisfy this need. Yet the brain is also a physical organ that plays by many of the same rules as the heart, lungs, liver and kidneys. To stay healthy and perform optimally it requires quality nutrition, physical activity and optimal sleep.

The brain, especially, relies on a healthy vascular system to efficiently deliver oxygen and key nutrients and remove waste. In fact, the brain uses approximately 20% of the oxygen we breathe to satisfy its high-energy demands. Given that the brain only weighs about 2% of the body, we can consider it an energy hog and we must cater to its needs very carefully.

Brain Food

Nutrients play key roles in brain function. Several have shown efficacy in clinical trials treating cases of mood disorders, cognitive decline and of course benefiting the physical health of the brain. Nutrients are both the raw materials employed in creating new neural connections and important components in regulating the activity of genes involved in these processes. Specific nutrients involved in mitochondrial efficiency, the energy factories of brain and body cells, are particularly important for many aspects of brain function. Other nutrients are involved in the inner workings of neuronal membranes, responsible for ensuring that electrochemical signals, which make up our thoughts, transmit efficiently and reliably. Finally, antioxidants, important throughout the body, are especially important in the brain due to its high energy production rates and concurrent high capacity for free radical leakage. Keeping this in mind, it is readily apparent that nutrition provides the building blocks for our brain’s structure and function, and therefore cannot be ignored.

Building Brain Muscles

Exercise is a clearly established component for promoting brain health as well. No longer can we think that the brain is completely separate from the brawn. Human studies have shown the value of exercise in controlling stress and maintaining positive mood states; in improving cognitive function, including performance on memory and executive tasks; and in improving the brain’s two-way communication streams with the rest of the body. Some of these benefits are likely due to the positive effects of exercise on neurovascular health, which parallel cardiovascular health. Other benefits seem due to increased grey matter in ‘front office’ functions of the cortex; and neuronal birth, or neurogenesis, in the hippocampus, a brain region that controls aspects of memory and mood regulation. Whatever the mechanism, giving your body a workout will produce substantial benefits in terms of brain health. Remember, a body in motion tends to stay in motion, and your brain and body will be together your whole life.

Mental Workouts

Mental activity is an obvious, and critical, ingredient for optimizing and maintaining brain function. Studies have established relationships between the degree of life-time mental activity and late-life cognitive function. It’s clear that those who engage in intellectually challenging endeavors on a regular basis reap the benefits of a clear mind. There is, however a need for each individual to balance sufficient variety with a proper degree of challenge. Without variety and challenge, tasks become too mundane and too easy, eventually growing stale and losing their capacity to adequately stimulate the brain. We must also realize that mental activity goes beyond ‘cognitive’ tasks. Mental activities also include practices like meditative focus, relaxation and stress reduction techniques, as well as social interaction. These active and dynamic processes challenge the mind as well. Mixing cognitive challenges with emotional regulation provides a more complete mental workout that will help you to use it to improve it.

Rest and Regeneration

An often neglected component contributing to brain health is optimal sleep. On average, we sleep approximately 1.5 hours per night less than we did 100 years ago. Modern technology makes it easier to get less sleep and our busy lives encourage us to do it. Sleep is far more than a time of rest, and is too often misclassified as a period of lost productivity. It is an active metabolic period for our brains. Sleep is a time when we consolidate memories of the previous day, a time when we re-synchronize the circadian rhythm of at least dozens, if not hundreds, of hormones controlling our metabolism. Sleep loss is associated with a high percentage of mood disorders and certainly reduces our cognitive efficiencies. We must give ourselves permission to sleep by realizing that it is counterproductive to steal from it.

In BrainFit for Life: A User’s Guide to Life-Long Brain Health and Fitness, we focus equally on the cognitive, emotional and physical health of the brain and all of the lifestyle factors that come into play to maintain them. Today’s aging population is becoming increasingly focused on the maintenance of cognitive health and the value of ‘brain training’ programs. But we must realize that such training is not unlike that of an athlete, who must focus on their diet, sleep needs and psychological preparation in addition to their physical skill development. We explore specific aspects of nutrition, exercise, mental activity and sleep. We discuss how they regulate emotional, physical and intellectual functions of the brain. After all, they are not separable.

“To keep the body in good health is a duty…otherwise we shall not be able to keep our mind strong and clear.” - Buddha, circa 500 B.C.

BrainFit For Life is available at http://www.brainfitforlife.com/book.php

Written by Simon Evans

We’ve written before about the benefits of Tai Chi for your brain fitness and your immune system. In fact, we go into some detail on this topic in a couple sections of our new book, BrainFit for Life. Now a new study shows some striking effects of a year-long Tai Chi program at dramatically reducing cardiovascular disease risk factors.

The new paper published by Chin Lang et al. in the Journal of Complementary and Alternative Medicine details the evaluation of 53 patients with clinically problematic high cholesterol or triglycerides. About half of the patients in this study participated in a 12-month Tai Chi program while the other half continued their typical sedentary lifestyle. Since all of the patients were classified as high risk for cardiovascular illness, they remained on cholesterol reducing medication in both groups.

The group that received Tai Chi saw a significant improvement on many fronts. Their blood pressure dropped, their total cholesterol and ‘bad’ cholesterol (LDL) went down, their insulin levels decreased and markers of excess inflammation fell as well. The sedentary control group saw a slight reduction in blood pressure but their cholesterol and triglyceride levels actually got worse - even though they remained on cholesterol reducing medication (chalk up another point for exercise).

Beyond these blood markers, the Tai Chi group also experienced improvements on measure of physical fitness. They significantly improved their exercising heart rate, oxygen uptake and ventilation. The sedentary group saw no such benefits, and, in fact, saw a decline in several fitness markers.

This study provides more positive data for the health benefits of Tai Chi. Why is it so good for you? No one really knows the definitive answer to that, but there are likely many factors.

First, Tai Chi involves slow and deliberate movements that help regulate breathing and focus, which contributes to better stress management. A plethora of studies have shown the health boosting benefits of reducing stress, so this alone is a major plus.

Second, Tai Chi provides moderate levels of exercise that mixes cardiovascular with strength training - holding those poses ain’t easy. Even though the movements are slow, practitioners experience a sustained elevation of heart rate. Maybe not as much as shakin’ your booty in a jazzercise class, but elevated all the same.

Third, Tai Chi helps improve balance and coordination. This is a huge benefit for older folks, since falling is the number one cause of injury in this age group. Younger folks glean benefit from this aspect as well, especially anyone engaged in athletics. Balance control is central to performance in many sports.

Fourth, often times, folks perform Tai Chi in a group setting, involving the social support aspect. We have written about the huge benefits of social support in the past. In fact, a couple other recent studies found that social support significantly helps recovery from a stroke or heart attack while social isolation makes it worse.

Tai Chi, considered a ‘soft martial art’, has been around in Chinese culture for a couple hundred years and is now making its way to the rest of the world. It shouldn’t be that difficult anymore to find a Tai Chi class in a community near you. Whether you’re a busy professional needing to reduce some stress, a retired individual needing to keep your brain and body fit or a patient fighting an illness, Tai Chi seems to have a little something for everyone.

Reference: Journal of Complementary and Alternative Medicine (2008) 14:7, 813-819.

By Paul Burghardt, PhD

Here’s one for the notebook. People who exercise regularly obtain greater elevation in mood following a single exercise session compared to people who don’t exercise regularly. This was revealed in a recent study by Hoffman & Hoffman (2008) in the Archives of Physical Medicine and Rehabilitation.

What?! Who?!?! How?!?!?…. It just doesn’t seem fair. Isn’t exercise supposed to elevate mood for everyone!?!?

At this point, you might be saying to yourself, “There’s no point in starting an exercise program, you only get improvements in mood if you exercise regularly.” Easy there Debbie Downer, there are still plenty of reasons to increase your physical activity or start exercising.

Digression Alert!

For those of you who are unfamiliar, Debbie Downer is a character from a Saturday Night Live skit. She could transform anything that anyone said into a completely depressing anecdote. Debbie was not just a ‘glass half empty’ type of person, she was a ‘dirty glass is a three-quarters empty and it dropped and broke on the floor’ type of person. Your can follow this link to check her out. If for no other reason than it is one of the rare occasions on SNL when the cast has a difficult time ‘keeping it together.’

Back to the Science!

To recap, we were talking about how it was unfair that people who exercise regularly experience a greater elevation in mood after a single session of exercise than people who don’t exercise.

There was a couple of interesting things about this study. First, this study looked at people who were, on average, in their early 40’s. It isn’t uncommon for these types of studies to look at college-age kids or people that are in the autumn of their lives. So this snap shot of the middle portion in life is pretty interesting.

Second, this study required people from each group to exercise at the same level of perceived exertion. Everyone performed a warm-up that felt very light, and then ran on the treadmill for 20 minutes at a pace that felt somewhat difficult. An important issue to note is that those who exercised regularly were likely working at a higher absolute intensity compared to people who were sedentary. For example, regular exercisers might warm up at a pace of 4 miles per hour, whereas the sedentary people may have warmed up at 2 miles per hour…but it felt the same to both groups.

This is the main idea behind perceived exertion. There are several tools, questionnaires really, available to measure how difficult exercise feels to an individual. A commonly used scale for exercise is the Borg-scale which measures 6-20. A perceived exertion of 6 would feel like the person was resting comfortably. A perceived exertion of 20 would be a scenario where the person would feel like they are working as hard as they possibly could; for example sprinting uphill. What is really cool about this scale is that you can often match the person’s subjective verbal rating of exertion to an objective measure of heart rate.

What do I mean? Basically you take their reported exertion score on the Borg-scale, let’s say 12, and multiply it by 10 to get the person’s heart rate; in this case 120 beats-per-minute. When researchers do that, they’re typically not that far off from the heart rate actually measured.

Now you might be thinking, “hey, Debbie has a point, if I don’t exercise regularly, then why start? I won’t get anything from it.” Well that’s not true. This study showed that people who exercise regularly obtained a greater enhancement of mood following a single bout of exercise compared to those who don’t exercise regularly. But, those who didn’t exercise regularly still experienced an improvement in mood following a single exercise session.

So you can be an ultra-marathoner, a regular exerciser, or a couch potato and still experience some elevation of your mood after a single session of exercise. The thing you need to realize is that you’ll feel even better if you can make exercise a normal part of your routine. However, is that improvement in mood enough motivation for sedentary people?

The authors of this article raise this very interesting point. Namely, that the elevation in mood experienced by sedentary individuals after a single exercise session may not be substantial enough to surpass that experienced by less healthy activities. To translate, you might get more of a temporary elevation in mood from sitting on the couch eating potato chips and watching TV than if you go out for a walk. That is to say, if you are just starting to incorporate exercise into your daily routine.

This is where it helps to have some foresight and look to the future. You will continually build on your past efforts, your previous investments so to speak. As you develop your physical reserve it pays out larger dividends. It’s very similar to compound interest. The more you save, the more you have available to earn interest on partially due to what you put in, and partially due to what is paid back into your account by your own investment.

An interesting parallel to the benefits of building up a ‘physical’ bank account is the ability to withdraw from what you have accrued. If we’ve built up sufficient savings in our account, for a rainy-day, we’ll be better able to handle the unexpected challenges that life inevitably will through our way. Just remember, it takes some time to build a big enough bank account that you can take vacation for a month.

Hopefully, this information will give you some extra motivation to make it through the initial weeks when first starting an exercise program. I know it’s can be difficult to maintain in the beginning. However, it appears that if you can maintain it you will be rewarded. So take heart, it will get easier and ultimately make you feel better.

By Simon J. Evans, PhD

The title question may be a bit of a stretch, but you only need to connect a couple of research dots to get from childhood obesity to reduced brain fitness in older age.

Belly Fat and Brain Fitness are Related

First, a recent meta-analysis from researchers at Johns Hopkins University verified that the odds of getting Alzheimer’s and other types of dementia increase as you gain weight. A meta analysis takes all previous studies on a particular topic and looks at them together to improve the statistical power over any one study by itself. This particular meta analysis looked at all studies that evaluated whether or not risk for Alzheimer’s or other types of dementia is increased in obese individuals.

Some studies evaluated obesity status of people in their mid-forties, others looked at people in their mid-sixties or seventies. In any case, obesity in mid-life or late life increased odds of getting Alzheimer’s disease or other dementias anywhere from 10 to 30 years later. Importantly, researchers controlled for socio-economic status, lifestyle choices, genetic factors and other illnesses so that the condition of obesity itself, seemed to be the culprit.

Adolescent Weight Problems Lead to Adult Weight Problems

The second dot to connect is that being overweight in childhood dramatically increases the odds of battling a weight problem throughout adulthood. So giving in to your kids’ demands for cakes, cookies and sugared cereals now, is not doing them any favors down the road.

There are really two ways to pack on the pounds. One is to make more fat cells, and the second is to store more fat in the fat cells you already have. An important study from the Karolinska Institute in Sweden, discovered that the number of fat cells you will carry throughout your adult life is really set during your adolescent years. After the age of 20, your number of fat cells will stay about constant.

Obviously, this doesn’t mean that your weight is set after age 20. You can still lose weight or dramatically gain weight. It’s not uncommon to gain weight in your 30s and 40s, as your activity level and metabolism slow down, especially if your food intake doesn’t change. You can always lose or gain fat in the cells that you already have. However, if you gain too much weight in adolescence, when you are actively making more fat cells, you are going to set yourself up for a tough battle for the rest of your life. So as parents, we should do everything possible to regulate our kids weight while it’s still somewhat in our control.

If you connect these two lines of research, you can see that increased weight gain in childhood predicts increased obesity in adulthood; and increased obesity in adulthood boosts your odds of Alzheimer’s and dementia in your 70s and 80s. There have not been any research studies following kids all the way from adolescence to old age to look directly at the relationship between childhood weight and dementia, but they will come eventually. Personally, I won’t be surprised if these studies find increased odds of dementia with childhood obesity.

It’s difficult to think of our kids as old people, but that is who they will become. We must think proactively and do everything we can to boost their odds of life-long cognitive success. If you have concerns about your own children’s weight, work with your pediatrician to design a diet and exercise program and get it under control while you still can. If you struggle with a weight problem yourself, don’t give up. The more effort you put in to bringing your weight under control, the better your odds of a fit brain down the road. Even if you only drop some of the weight you want to lose, every little bit helps boost those odds.

References:

Nature (2008) Jun, 453(7196):783-7

Obesity Reviews (2008) May, 9(3):204-18

By Simon J. Evans, PhD

If you talked to a person from the 1950s about all the modern marvels we have today they’d likely drool at the mouth. What? You don’t have to get up to change the TV channel? You can reheat leftovers in 1 minute? You can access any information at any time without leaving your house? No way!

Be Careful What You Ask For

But are our lives really getting any easier? Do all these time saving devices allow us to work less? Well, sort of. It certainly takes less work to do any specific task. When I was in graduate school writing my thesis, I thought of the poor slobs who had to do that without the aid of a computer or the internet. It must have taken people an entire day to go to the library to find references that I can now get in 10 minutes (God bless Google). The trade-off is that we are expected to do a lot more tasks as part of our normal day.

I was reading an interesting paper by Kelly Lambert recently that put some of this into perspective as it may relate to rates of depression in our modern society. Even with all our modern conveniences, high-end medical care and plethora of designer drugs, we have a huge mental health crisis. In fact, today mental health accounts for about 15% of disease burden worldwide. So why are we so unhappy?

The Thrill is in the Chase

Dr. Lambert argues that one factor in our overall societal unhappiness is the fact that we have it too easy, especially when it comes to feeding ourselves. Years gone by, dinner was more than a phone-call away. We actually had to track our food across the tundra and risk death by saber-toothed tigers or violent weather, in order to feed ourselves. Even if we were successful, we had to do it again the next day. As time drew on, we learned it was much easier to plant food in the ground. But this still required intensive labor and patience to bring our sowing efforts to the fruition of harvest.

All of this effort made the reward that much more enjoyable. The magnitude of the reward may actually depend on the magnitude of the effort required to achieve it. Meaning the harder we have to work for something, the more we enjoy it when we are successful. Since successfully finding food is a major factor in our survival, and we used to work very hard to stay fed, we had ample opportunity for regular high intensity rewards.

Appreciate What You Have

Today, however, we take for granted this major facet of our lives. Finding food does not require much effort at all, at least for most of the lucky people living in our society. Because we don’t need to put out effort, we don’t activate reward centers in our brains that our ancestors activated on a regular basis. We are essentially robbing ourselves of a major ‘happiness factor’, and this, argues Dr. Lambert, may be a problem. It may be that today’s lack of regular reward, due to lack of necessary effort, may be a factor in high rates of depression.

Whether or not she is right, I don’t know. She provides many examples and scientific studies to back up her argument and I thought it was a very interesting point worthy of a post. In fact, I have two cats that seem to agree with her. They are not content just eating their chow out of a dish. Instead, they enjoy scooping out one nugget at a time, batting it across the kitchen floor and then pouncing on their prey before eating it.

There’s not really much we can do about this unless you want to pull a Grizzly Adams and drop out of society, move to the hills and live off the land. Alternatively, you could do all your grocery shopping in full camouflage, crawling around on your belly through the frozen food aisle, stalking fish sticks. Or, maybe we can be more appreciative of what we have and not take all our modern conveniences for granted.

Reference: Lambert, K.G. Neuroscience and Biobehavioral Reviews 30 (2006) 497–510

By Dr. Simon Evans and Dr. Paul Burghardt

For some time now, we’ve been promoting the role of a healthy lifestyle in maintaining brain fitness. Another new study lends more support, but before we get into that we thought we’d focus on some common-sense topics as to why this is true.

One simple concept to understand that doesn’t require a PhD is the fact that any organ in your body, including your brain, needs a healthy blood supply to access nutrients and oxygen. This is one reason why heart disease and mental health problems, including dementia are so often related. If you tied a tourniquet around your leg to cut-off the blood supply, you shouldn’t be surprised when your foot stops working to well.

The same is true for your brain. If you continue to do things that are bad for your cardiovascular system, like sit around all day and eat chips, your vascular system will eventually have a problem, and this is not good news for your brain. In fact, your brain uses about 20% of the oxygen that you breathe and the calories that you eat. Your blood supply is responsible to get that stuff to the right place in order to keep your brain in good working operation.

The benefits of life-long learning and continually challenging your mind to keep it sharp are well established. But if you don’t couple that effort with doing what’s necessary to maintain a healthy neurovascular system, you cannot fully realize the benefit. You may have read a lot about neurogenesis and synaptogenesis, which is the constant rewiring of your brain that occurs when you stay mentally active and helps to keep your mind agile. However, this process can only work well if the blood vessels near all this rewiring are healthy enough to do their job. Otherwise, where is the energy, nutrients and oxygen necessary for the remodeling job going to come from?

Think of neurogenesis as a new housing subdivision going into an existing community and the roads as the blood supply to service the houses. If you were the builder constructing this new development you wouldn’t get very far if you didn’t first attend to the new roads. Not only are the roads needed for the new owners to get in and out of their homes; but they are needed for delivering all the lumber and concrete, enabling the different crews to come in and construct the new houses, and take all the trash away. Similarly, new brain cells or new brain cell connections need healthy roads (neurovascular system) to work right.

Related to this, a recent large study, just unveiled this month (April 2008) by Dr. Thomas Montine from the University of Washington, reports that 33% of the risk of dementia stems from disease of small blood-vessels in the brain. In this 12-year study, 3,400 men and women over age 65 volunteered for periodic cognitive testing and a brain autopsy upon their death. In the 221 autopsies performed, researchers discovered that small blood vessel disease accounted for about 1/3 of the risk for dementia. Importantly, this type of small blood vessel disease may go unnoticed for some time. We’re not talking about big events like a stroke or blood clot blocking a large vessel. However over time these small problems can add up, and result in cognitive impairment.

Admittedly, this study comes from the Pacific Northwest, the origin of grunge-rock and Starbucks coffee. We can’t be sure that all these people aren’t suffering from some kind of post-angst cognitive disorder, or a latent flannel shirt allergy! We also can’t rule out suffering from some sort of post-tramautic stress after invading the world with high-priced coffee, equivalent to about $18.00 per gallon; slightly more than we’re currently paying for gas. In fact, one of us (Evans) was raised in Seattle and may be showing some early symptomology.

However, with these potential confounds aside (unless Austin Powers was right, and during the time that Dr. Evil was cryogenically preserved his faithful cronies invested heavily in Starbucks), this study is an incredibly important step that illustrates the diversity of factors that can lead to dementia. Even more importantly, it suggests that you can substantially decrease your odds of developing dementia by attending to life-style factors that can protect against vascular disease.

The beauty is that we have a good idea of how to do this since blood vessels serve to supply active areas of the body with nutrients! So if your brain is active (which requires energy), and you’re maintaining your overall vascular health by eating right and exercising, odds are that you will be greatly reducing your risk of developing dementia from small vessel disease. Now it should be noted that research is ongoing on this subject, but common sense would suggest that this will hold true.

Taken together this highlights some very important reasons as to why exercise and nutrition play such a crucial role in brain fitness. Attending to both of these lifestyle factors is necessary to maintain a healthy blood supply and the creation of new blood vessels, in order to feed new brain circuits established by learning and mental activity. If you neglect this aspect of brain fitness, you may literally limit your ability to benefit from neurogenesis and synaptogenesis induced by many of the ‘brain-training’ programs designed to keep your mind young.